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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Fig. 4

In vivo administration of extracellular MOG mRNA-electroporated tolDC abrogates EAE development. a Clinical follow-up of mice treated with 1 × 106 viable non-antigen-loaded and non-electroporated tolDC (n = 13), MOG35–55-pulsed tolDC (n = 13), MOG mRNA-electroporated tolDC (n = 13) or PBS (n = 14). Arrows represent days of treatment (day 13 pi, day 17 pi, and day 21 pi). Results are represented as mean ± standard error of the mean. b Marginal average evolutions of the clinical score, as generated by the non-linear model described in the “Materials and methods” section; *p < 0.05. N.S. not significant, PBS phosphate-buffered saline

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