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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

Fig. 1

Mdivi-1 ameliorates the severity of EAE and demyelination. C57BL/6 mice were immunized with MOG35–55, Mdivi-1 (25 mg/kg) was given intraperitoneally, and 0.1% DMSO was established as control (n = 15 each group) in a similar manner on day 3 p.i., until day 27 p.i. Lumbar regions of spinal cords were harvested for LFB staining and immunostaining of MBP. a Clinical score of EAE mice, and b representative microphotographs for demyelination (Luxol Fast Blue staining and MBP immunostaining) and quantitative analysis of demyelination of whole spinal cord white matter lesions. Data represent mean ± SEM (n = 7–9 each group). *P < 0.05; **P < 0.01; ***P < 0.001. One representative of two experiments is shown

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