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Table 1 Clinical evaluation of mice with EAE

From: Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

Group Disease onset Disease incidence (%) Peak score Cumulative disease score
DMSO (n = 15) 13.1 ± 0.7 95% 3.6 ± 0.4 42.9 ± 5.5
Mdivi-1 (n = 15) 13.4 ± 0.6 65%* 1.8 ± 0.5* 16.4 ± 5.6**
  1. Mdivi-1 was intraperitoneally administered at 25 mg/kg daily starting from day 3 p.i. Disease onset was defined as the first day of 2 consecutive days with a clinical score. Disease incidence was defined as the percentage of mice that displayed any clinical signs of disease. Cumulative disease scores were calculated as the sum of all daily scores of each individual mouse divided by the number of mice in each group. *P < 0.05, **P < 0.01, DMSO vs. Mdivi-1-treated mice