Group | Disease onset | Disease incidence (%) | Peak score | Cumulative disease score |
---|
DMSO (n = 15) | 13.1 ± 0.7 | 95% | 3.6 ± 0.4 | 42.9 ± 5.5 |
Mdivi-1 (n = 15) | 13.4 ± 0.6 | 65%* | 1.8 ± 0.5* | 16.4 ± 5.6** |
- Mdivi-1 was intraperitoneally administered at 25 mg/kg daily starting from day 3 p.i. Disease onset was defined as the first day of 2 consecutive days with a clinical score. Disease incidence was defined as the percentage of mice that displayed any clinical signs of disease. Cumulative disease scores were calculated as the sum of all daily scores of each individual mouse divided by the number of mice in each group. *P < 0.05, **P < 0.01, DMSO vs. Mdivi-1-treated mice