Fig. 3

PET imaging findings in rats treated with pFUS+MB (a) Ex vivo T2*-weighted MR images showing multiple hypointense foci in the sonicated frontal region (red box) and the right hippocampal region (white box) suggestive of extravasated red blood cells, microhemorrhagic changes and hemosiderin within phagocytic cells. b Three examples of [18F]DPA-714 PET scans showing increased binding in the sonicated regions after one, two, and six sonication sessions respectively. c Ratios of [18F]DPA-714 binding (sonicated/non-sonicated mean %ID/cc values) in both sonicated regions following one (1×), two (2×), and six (6×) sonications. No increased [18F]DPA-714 seen in the cerebellar hemispheres which were not sonicated. d Longitudinal mean ratios of [18F]DPA-714 binding in a subset of animals after two (2×) and six (6×) sonications. No statistically significant differences were detected in the sonicated regions or in the cerebellum (control region) (Paired t-test, p > 0.05). Error bars represent standard deviations