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Table 1 Mean ratio of [18F]DPA-714 binding (sonicated/non-sonicated) in the frontal cortex and hippocampus in all three groups of animals. The cerebellum was not sonicated and is used as control

From: In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study

Region of interest

Mean ratio of ipsilateral/contralateral

1 sonication

N = 6

2 sonications

N = 8

6 sonications

N = 5

Frontal cortex

1.47 ± 0.2

1.53 ± 0.2

1.53 ± 0.3

Hippocampus

1.31 ± 0 .1

1.83 ± 0.5

1.61 ± 0.5

Cerebellum

1.03 ± 0.04

1.02 ± 0.07

0.98 ± 0.12