Fig. 7

Immune response genes that are upregulated in microglia and infiltrating macrophages during neuroinflammation. Using the BaseSpace correlation engine, we identified a 201 immune response genes that were differentially expressed in the analysis comparing infiltrating macrophages from TMEV-infected brains vs homeostatic microglia from PBS-injected brains. Fold change of the 20 most highly enriched immune response genes in b homeostatic microglia relative to infiltrating macrophages; c infiltrating macrophages relative to homeostatic microglia. d 152 immune response genes that were differentially expressed in the analysis comparing infiltrating macrophages from TMEV-infected brains vs reactive microglia from TMEV-infected brains. Fold change of the 20 most highly enriched immune response genes in e infiltrating macrophages relative to reactive microglia; f reactive microglia relative to infiltrating macrophages. g 108 immune response genes that were differentially expressed in the analysis comparing reactive microglia from TMEV-infected brains vs homeostatic microglia from PBS-injected brains. h Fold change of the 20 most highly enriched immune response genes in reactive microglia relative to homeostatic microglia. i Fold change of the few enriched immune response genes found in homeostatic microglia relative to reactive microglia. All analyses were performed using the BaseSpace correlation engine