Fig. 7
From: The retinal environment induces microglia-like properties in recruited myeloid cells
Irradiation of the retina compromises microglia survival leading to their replacement by donor bone marrow cells following ONC. a, b Analyses of retinal CD11b+CD45+GFPlo and CD11b+CD45+GFPhi cells in normal (non-chimeric, no ONC) B6-CD45.1 and CD45.2 CD11cDTR/GFP mice. c ONC response in normal CD11cDTR/GFP mice. d, e Analysis of CD45+ cells in the retinas of chimeric mice with or without ONC. Chimeric mice received 2 × 6 Gy of radiation and were unshielded. Retina was analyzed by flow cytometry for recipient (CD45.1) and donor (CD45.2) cells. ONC was done 5 weeks post-bone marrow transfer with retinas analyzed 7 days post-ONC. Cell numbers are given as mean ± SD with number of retinas in each group indicated