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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury

Fig. 3

Treg depletion did not affect the overall neurological outcome but transiently aggravated motor deficits after CCI. a–c Body weight, neurological impairment (NSS), and rotarod performance of DEREG and WT mice (n = 11–12, each genotype). Body weight and rotarod performance are expressed as ∆ relative to pre-injury values (set to 0). a Relative body weight loss at 1 dpi and 5 dpi was similar between DEREG and WT mice. b NSS at 1–5 dpi were not significantly altered between DEREG and WT mice but DEREG mice showed a trend towards an increased NSS at 1 dpi (p = 0.08). c Motor deficits assessed by rotarod performance were transiently aggravated in DEREG at 1 dpi but not at 5 dpi compared to WT mice. Data are expressed as mean ± SEM. Statistical significance between DEREG and WT mice was calculated using two-way ANOVA followed by Sidak’s multiple comparison test (**p < 0.01)

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Journal of Neuroinflammation

ISSN: 1742-2094