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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury

Fig. 8

Increased gene expression of T cell marker and IFN-γ in the brain tissue from DEREG mice after CCI. a–h Histograms showing mRNA expression of T cell marker genes (Cd247, Cd8a) and inflammatory marker genes (Ifng, Il10, Il1b, Il-6, Tnfa, and Cd74) in WT and DEREG mice as determined by qRT-PCR at 5 dpi. Data from ipsilesional and contralesional brain tissue samples are shown. b–d Note that Cd8a, Ifng, and Il10 gene expression levels in the contralesional brain tissue samples were below the detection threshold. Data are expressed as mean ± SEM, and p values were calculated by Student’s t test (b–d; *p < 0.05) or by one-way ANOVA followed by multiple comparison using Tukey’s or Dunn’s post hoc test (a, e–h, *p < 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094