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Table 3 HLA conditional analysis of multiple sclerosis in the Japanese population

From: Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

Variant

Frequency

Conditional association

DRB1*15:01, DRB1*04:05, B*39:01, and B*15:01

HLA gene

MS (n = 45)

Control (n = 429)

OR (95% CI)

P

HLA-DRB1*15:01

0.211

0.072

4.06 (2.22–7.45)

5.7 × 10−6

HLA-DRB1*04:05

0.233

0.120

3.02 (1.72–5.31)

1.2 × 10−4

HLA-B*39:01

0.122

0.043

4.13 (1.96–8.71)

1.9 × 10− 4

HLA-B*15:01

0.200

0.078

3.10 (1.70–5.65)

2.3 × 10−4

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Journal of Neuroinflammation

ISSN: 1742-2094