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Table 4 HLA association analysis with the clinical course of MS

From: Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

 

Number of patients

EDSS

P (Student’s t)

A

 HLA-DRB1*15:01 positive

18

3.08

0.990

 HLA-DRB1*15:01 negative

27

3.09

 

 HLA-DQB1*06:02 positive

17

3.41

0.472

 HLA-DQB1*06:02 negative

28

2.89

 

 HLA-B*15:01 positive

15

4.20

0.098

 HLA-B*15:01 negative

30

2.53

 

 HLA-B*39:01 positive

11

3.50

0.504

 HLA-B*39:01 negative

34

2.96

 
 

Number of patients

Age of onset

P (Student’s t)

B

HLA-DRB1*15:01 positive

18

33.3

0.618

HLA-DRB1*15:01 negative

27

35.0

 

HLA-DQB1*06:02 positive

17

33.0

0.545

HLA-DQB1*06:02 negative

28

35.1

 

HLA-B*15:01 positive

15

35.1

0.752

HLA-B*15:01 negative

30

33.9

 

HLA-B*39:01 positive

11

30.0

0.142

HLA-B*39:01 negative

34

35.7

 
  1. *Student’s t test was used for association analysis