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Table 5 HLA association analysis of neuromyelitis optica spectrum disorder in the Japanese population

From: Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

Variant

Frequency

Nominal analysis

HLA gene

NMOSD (n = 31)

Control (n = 429)

OR (95% CI)

P

Fisher

HLA-A*26:03

0.065

0.020

3.40 (0.81–10.9)

0.047

*

HLA-B*07:02

0.129

0.059

2.34 (1.06–5.19)

0.036

 

HLA-DPB1*05:01

0.516

0.356

1.93 (1.15–3.24)

0.012

 

HLA-DQA1*01:01

0.129

0.058

2.39 (1.08–5.30)

0.031

 

HLA-DQA1*03:02

0.048

0.147

0.30 (0.06–0.93)

0.035

*

HLA-DQA1*05:03

0.097

0.015

6.96 (2.55–19.0)

1.5 × 10−4

 

HLA-DQB1*03:01

0.210

0.104

2.29 (1.20–4.39)

0.012

 

HLA-DQB1*03:03

0.048

0.149

0.29 (0.06–0.91)

0.024

*

HLA-DRB1*01:01

0.129

0.058

2.39 (1.08–5.30)

0.031

 

HLA-DRB1*09:01

0.016

0.135

0.10 (0.003–0.62)

0.0027

*

HLA-DRB1*14:06

0.081

0.012

7.40 (1.92–24.8)

0.0021

*

  1. *Fisher’s exact test was used for association analysis, otherwise, logistic regression was used
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Journal of Neuroinflammation

ISSN: 1742-2094