Fig. 8
From: Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model
Effects of the treatment with an anti-TNFSF10 monoclonal antibody on the expression of either Aβ 1–42 (panel a) and phosphorylated Tau protein (p-TAU) (panel b) in the hippocampus of 3xTg-AD mice: representative immunofluorescence images of hippocampi from each animal group (merge column; DAPI = nuclear staining). The respective left-hand side columns are the samples where the areas to be magnified for analysis were picked (green frame boxes; CA1, CA2, CA3, and CA4). Panels (a’, b’): densitometric count of immune-positive cells, for, respectively, Aβ 1–42 and p-TAU. *p < 0.001 3xTg-AD mice untreated vs WT-vehicle; **p < 0.001 3xTg-AD mice treated with anti-TNFSF10 vs. untreated 3xTg-AD mice (one-way ANOVA, followed by a Duncan’s multiple range test). Vertical bars are means ± S.E.M. WT wild-type animals (n = 5/group); AD: 3xTg-AD animals (n = 5/group)