Fig. 2

LPA₁ knockdown reduces brain damage in tMCAO-challenged mice. LPA₁ shRNA (shLPA₁) and non-target control shRNA (shNC) particles were injected into the ventricle. One week later, mice were challenged with tMCAO. Brain damage was assessed at 1 day after tMCAO challenge. a–c Effects of LPA₁ knockdown on infarct volume (a, b) and neurological function (c) were determined. Representative images of TTC-stained brain slices (a) and quantification of brain infarction (b). Neurological score indicating neurological functions (c). n = 7 mice per group. **p < 0.01 versus non-target control lentivirus injected tMCAO mice (tMCAO+shNC)