Fig. 2
Low dose Ad-TMBIM6 reduced percent infarcted area and improved long-term neurobehavioral outcomes. Quantitative analysis of TTC stained sections for the percent infarcted area at 72 h post-HI (a). Quantitative analysis of viral vector present in the brain and representative images of immunofluorescent staining of expression of virus (red) on neurons (green), microglia (green) and astrocytes (green) at 72 h post-HI (b) (scale bar = 25 μm). Long-term neurobehavioral tests: total distance in rotarod test (c) and time to platform in water maze test (d) at 4 weeks post-HI (data expressed as mean ± SD; an asterisk indicates p < 0.05 vs sham; number sign p < 0.05 vs vehicle; @ p < 0.05 vs Ad-TMBIM6 (1.6 × 1011 PFU); n = 6–9. One-way ANOVA followed by Tukey’s multiple-comparison/or Holm-Sidak post hoc analysis)