Fig. 1
PLG is depleted in the plasma of PLG ASO-treated animals and many monocytic cells throughout the body express PLG-RKT, the purported receptor responsible for PLG-mediated chemotactic migration. a Representative Western blot of PLG and transferrin (TF) levels in the plasma of CTRL ASO- and PLG ASO-treated mice. PLG-RKT is expressed b on leukocytes (CD11b+ cells, red) in the blood and c on IP macrophages (CD11b+ cells, red) isolated from the peritoneal cavity. PLG-RKT expression is also observed on perivascular macrophages (CD206+ cells, red) in the brains of these mice (Fig. 3b of the manuscript). Scale bar, 100 μm. n = 3 sections/brain, 5–7 mice/group