Fig. 3
PVM accumulation in the brain increases with LPS challenge and is mediated by plasma PLG. a Representative images and quantification of PVMs (CD206, green) in blood vessels of the brain (Col IV, red) in CTRL or PLG ASO-treated mice challenged with LPS or PBS. CD206 staining increases with LPS injection (p < 0.001) in CTRL ASO mouse brains but returns to control levels in PLG-deficient mice challenged with LPS (p < 0.001). b PLG-RKT (green) is expressed on PVMs (red, CD206+ cells) in the brains of these animals and could be aiding in the migration of PVMs into the brain during LPS challenge. Scale bar, 100 μm. n = 3 sections/brain, 5–7 mice/group