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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Fig. 10

Intraperitoneal injection of dasatinib significantly downregulates LPS-stimulated COX-2 levels in wild-type mice. a, c Wild-type mice were injected with dasatinib (20 mg/kg, i.p.) or vehicle (4% DMSO + 30% PEG + 5% Tween 80, i.p.) daily for 4 days, followed by injection with LPS (10 mg/kg, i.p.) or PBS. Three hours after LPS or PBS injection, immunohistochemistry was conducted with an anti-COX-2 antibody. b, df Quantification of the data in a and c (cortex: con, n = 8 mice; LPS, n = 9 mice; dasatinib+LPS, n = 9 mice; and hippocampus: con, n = 8 mice; LPS, n = 9 mice; dasatinib+LPS, n = 9 mice). One-way ANOVA with Tukey’s post hoc test was used to analyze significant differences. *p < 0.05, **p < 0.01, ***p < 0.001

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