Fig. 11

Intraperitoneal injection of dasatinib significantly downregulates LPS-stimulated IL-6 levels in wild-type mice. a, c Wild-type mice were injected with dasatinib (20 mg/kg, i.p.) or vehicle (4% DMSO + 30% PEG + 5% Tween 80, i.p.) daily for 4 days, followed by injection with LPS (10 mg/kg, i.p.) or PBS for 3 h. After 3 h, immunohistochemistry was conducted with an anti-IL-6 antibody. b, d–f Quantification of the data shown in a (cortex: con, n = 8 mice; LPS, n = 9 mice; dasatinib+LPS, n = 9 mice) and c (hippocampus: con, n = 8 mice; LPS, n = 9 mice; dasatinib+LPS, n = 9 mice). One-way ANOVA with Tukey’s post hoc test was used to analyze significant differences. *p < 0.05, **p < 0.01, ***p < 0.001