Fig. 2

The comparative expression of the microglial inflammatory-related genes. a Heat map and hierarchal clustering of the transcripts in cortical microglia at ZT2 and ZT14 of both WT and APP-KI mice. b A gene ontology analysis of genes associated with upregulated TTS in microglia from APP-KI mice at ZT14. The ten most significantly enriched biologic process (GO-BP) terms are shown. c The top ten transcripts in the cluster of “inflammatory response” in cortical microglia at ZT2 and ZT14 of both WT and APP-KI mice. Values are represented as counts per million (cpm) of three independent experiments carried out with microglia isolated from 12 2-month-old WT and 12 APP-KI mice.). The asterisks indicate a statistically significant difference from the WT ZT2 group (*P < 0.05, **P < 0.01, and ***P < 0.001, Student’s t test). The daggers indicate a statistically significant difference from the APP-KI ZT2 group (^{† †}P < 0.01 and ^{† † †}P < 0.001, Student’s t test)