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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Fig. 3

Diurnal changes of inflammatory factors in cortical microglia from 2-month-old WT and APP-KI mice. a, c, e, and g The mRNA levels of TNF-α (a), IL-1β (c), NOS2 (e), and IL-6 (g) were quantified using real-time PCR. Samples of each time point were pooled from three to four mice. Data are represented as the mean ± SEM of three independent experiments. The asterisks indicate a statistically significant difference from the WT group (***P < 0.001, two-way ANOVA test, interaction between time and genotypes). b, d, f, and h Average values of TNF-α (a), IL-1β (c), NOS2 (e), and IL6 (g) collapsed over the course of the day were calculated. Samples of each time point were pooled from three to four mice. Data are represented as mean ± SEM of three independent experiments. The daggers indicate a statistically significant difference from the WT group († †P < 0.01, † † †P < 0.001, two-way ANOVA test, interaction between genotypes)

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Journal of Neuroinflammation

ISSN: 1742-2094