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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Fig. 7

OAβ impairs the circadian clock in MG6 cells synchronized by Dex. a, c The relative mRNA levels of BMAL1 (a) and REV-ERBα (c) were examined in MG6 cells every 6 h over the course of 1 day after treatment with 100 nM Dex. b The relative mRNA level of BMAL1 were examined in MG6 cells 18 h after treatment with OAβ. d The relative mRNA levels of REV-ERBα were examined in MG6 cells 24 h after treatment with OAβ. The results in A-E are represented as the mean ± SEM of three independent experiments. The asterisks indicate a statistically significant difference from the control group (***P < 0.001, one-way ANOVA). The daggers indicate a statistically significant difference from the Dex group (†P < 0.05, † † †P < 0.001, one-way ANOVA test)

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