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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Effects of VEGF blockade on the dynamics of the inflammatory landscape in glioblastoma-bearing mice

Fig. 6

Distribution of immune cells in mouse physiological brain and GBM-bearing brain. Cubic-clearing treatment and 2P imaging of whole-brains of Thy1-CFP//LysM-EGFP//CD11c-EYFP mice. a 2P imaging of a half-cleared brain. Left panel, normal brain, no LysM-EGFP+ (not shown) or CD11c-EYFP+ cells could be detected. Right panel, tumor-bearing mouse at D28. Enlargement shows CD11c-EYFP+ cells traveling along the corpus callosum. b High-resolution five-color 2P imaging of a cleared GBM-bearing brain. Left panel, 3D sagittal view of the tumor showing distribution of fluorescent cells towards the tumor. Scale bar 500 μm. Right panel, view of fluorescent cells located below the tumor, around blood vessel, and along the corpus callosum. Scale bar 300 μm

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