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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function

Fig. 2

a Nrf-2 expression and localization in human STA (a, b) and IA (c, d). The decreased Nrf-2 expression and Nrf-2 nuclear translocation can be observed in magnified images (b, d) (scale bar = 10 μM). b Expression levels of VSMC-specific markers SM22α (red)/αSMA (green) and DAPI (blue) in human STA and IA (scale bar = 50 μM). The decline of VSMC-specific markers was detected in IA. c Representative pictures of the control and tBHQ groups for SM22α (red)/αSMA (green) and DAPI (blue) in immunofluorescence staining (scale bar = 50 μM). Photomicrographs show the increase of SM22α/αSMA in the tBHQ treatment group compared with the control. d Positive cells (cells with Nrf-2 translocation) numbers in A were analyzed (N = 3). Fluorescence intensity of specific VSMC markers in the STA/IA and control/tBHQ groups (N = 3). *p < 0.05 compared with the control group. STA, superficial temporal artery; IA, intracranial aneurysm; tBHQ, tert-butylhydroquinone

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