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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function

Fig. 5

Effects of Nrf-2 signaling on VSMC-specific markers, antioxidant enzymes, and inflammatory cytokines. Representative images of experiments performed in triplicate are presented. a Fold changes of Nrf-2, downstream antioxidant enzymes, and inflammatory cytokines mRNA levels. Data are the means ± standard errors of the mean. *p < 0.05 compared with the control group; #p < 0.05 compared with the H2O2 group. b Inflammatory cytokines analyzed by MILLIPLEX MAP Rat CVD Panel. Data are the means ± standard errors of the mean. *p < 0.05 compared with the control group; #p < 0.05 compared with the H2O2 group. c Western blot analysis of VSMC specific markers SM22α, and αSMA. Data are the means ± standard errors of the mean. *p < 0.05 compared with the control group; #p < 0.05 compared with the H2O2 group d Western blot analysis of Nrf-2 in the cytoplasm and nuclear fractions, antioxidant enzyme NQO-1, Data are the means ± standard errors of the mean. *p < 0.05 compared with the control group; #p < 0.05 compared with the H2O2 group  

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