Fig. 6From: Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and functionSchematic illustrating how Nrf-2 activation regulates phenotypic modulation. Under oxidative-stimulating conditions, Nrf-2 is activated and translocates into the nucleus. Nrf-2 signal pathway activation promotes expression of VSMC-specific markers SM22α and αSMA. The underlying mechanism may be that Nrf-2 upregulates expression levels of its downstream antioxidant enzymes and inhibits pro-inflammatory cytokinesBack to article page