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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function

Fig. 6

Schematic illustrating how Nrf-2 activation regulates phenotypic modulation. Under oxidative-stimulating conditions, Nrf-2 is activated and translocates into the nucleus. Nrf-2 signal pathway activation promotes expression of VSMC-specific markers SM22α and αSMA. The underlying mechanism may be that Nrf-2 upregulates expression levels of its downstream antioxidant enzymes and inhibits pro-inflammatory cytokines

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