Fig. 4

CNS Th-type responses to peripheral immune stimulation are sex- and strain-specific. Th-type cytokine responses were evaluated in brain lysates. Cortical IFN-γ; N = 3–6 per condition (a), IL-4; N = 3–5 per condition (b), IL-17; N = 7–11 per condition (c) and IL-10; N = 7–10 per condition (d) levels. IL-4 displayed only in female rats due to no differences seen in males; IL-10 and IL-17 levels collapsed between day. e Hippocampal Th-type cytokine levels in male rats at 2 days post-challenge; N = 3–5 per condition. Data represent mean +/− SEM, *p < 0.005, **p < 0.01, ***p < 0.001