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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain

Fig. 6

Minimal effects of treatment on IBA-1 immunoreactivity. The number of IBA-1 immunopositive cells was quantified in the cortex and hippocampus in response to treatment. a Representative photomicrographs of IBA-1 immunoreactivity and DAPI labeling in the cortex of BN rats; Sal=saline, Adj=adjuvant-only, Imm=immune challenge. Geometric mean ratio (GMR) plots displaying the number of IBA-1 immunopositive cells for treatment versus saline control in BN (N = 40; 18Imm(10M/8F), 18Adj(9M/9F), 4Sal(2M/2F) (b), and Lewis (N = 42; 15Imm, 15Adj, 7Sal) (c) rat strains. Data for IBA-1 immunopositive cell counts expressed as ratio over saline control conditions. Error bars represent 95% CI; a CI not including the normalization line (line at 1) indicates a significant difference between the treatment and saline controls at p ≤ 0.05. d Quantification of IBA-1/CD68 colocalization within strains and across treatment conditions, data expressed as boxplots illustrating the distribution of data points for each animal and the interquartile range

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