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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Fig. 3

OGD preconditioning-induced neuroprotection was attenuated by Notch1-RNAi in vitro. a Hippocampal neurons were identified by Map-2 antibody labeling (red), and the purity was over 95%. b Screening results of Notch1 RNA interference fragments. **P < 0.01 vs. Notch1-NC group. c, d The expression of NICD was significantly reduced by Lv-sh-Notch1. **P < 0.01 vs. Lv-NC group. e, f OGD preconditioning significantly improved hippocampal neuronal proliferation rates and reduced neuronal apoptosis after OGD/R. The neuroprotective effect was attenuated by Notch1-RNAi. Data are presented as the means ± SEM, *P < 0.05, **P < 0.01 vs. the control cell group; #P < 0.05 vs. OGD/R group. &P < 0.05, &&P < 0.01 vs. OGD-Pre + OGD/R + Lv-NC group

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Journal of Neuroinflammation

ISSN: 1742-2094