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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Fig. 6

RIPC-induced neuroprotection was attenuated by a Notch1 signaling pathway inhibitor in vivo. The neurological deficit scores and brain infarction volume were evaluated 24 h after reperfusion in rats in the 4 groups. a Images of focal cerebral infarction staining by TTC in coronal brain slices (white, infarct tissue; red, noninfarct tissue). b Brain infarct volume presented as a percentage of the intact hemisphere. Data are presented as the means ± SEM. **P < 0.01 vs. MCAO/R group, ##P < 0.01 vs. the RIPC + MCAO/R + DAPT group. c Neurological deficit scores are presented as the median with interquartile range. **P < 0.01 vs. MCAO/R group, ##P < 0.01 vs. the RIPC + MCAO/R + DAPT group

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