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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Fig. 8

RIPC activated the Notch1 and NF-κB signaling pathways in rats after MCAO/R. NF-ΚB signaling pathway activity was suppressed by the Notch1 signaling pathway inhibitor DAPT. a, b DAPT significantly decreased the expression of NICD in rats after RIPC + MCAO/R. **P < 0.01 vs. DMSO group. c Protein bands of NICD, Hes1, p-IKK α/β, p-NF-κB p65, Bcl-2, Bax, and β-actin from Western blot analysis. d, e RIPC significantly upregulated the expression of proteins related to the Notch1 and NF-κB signaling pathways. The Notch1 signaling pathway inhibitor DAPT reduced the activity of the NF-κB signaling pathway. Data are presented as the means ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 vs. the RIPC + MCAO/R group, #P < 0.05, ##P < 0.01 vs. the RIPC + MCAO/R + DMSO group

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