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Table 2 Comparison of the percentages of γδ T cell subsets between untreated MS patients, IFN-β-treated MS patients, and healthy controls

From: Long-term use of interferon-β in multiple sclerosis increases Vδ1Vδ2Vγ9 γδ T cells that are associated with a better outcome

 

Untreated MS (n = 35)

MS w/ IFN-β (n = 21)

HCs (n = 44)

p value (K-W test)

padj value

Untreated MS vs. HCs

MS w/ IFN-β vs. HCs

Untreated MS vs. MS w/ IFN-β

Vδ1+

29.0 (14.0–53.9)

29.6 (13.7–48.3)

18.4 (11.6–34.2)

NS

 Vδ1+Vγ9+

3.91 (1.26–10.2)

3.00 (1.60–5.17)

2.15 (1.12–4.71)

NS

 Vδ1+Vγ9

24.3 (10.2–40.8)

23.5 (10.0–38.3)

15.5 (8.47–31.5)

NS

Vδ2+

32.9 (13.3–52.3)

21.2 (5.07–33.4)

54.9 (31.7–65.9)

< 0.001

0.047

< 0.001

0.017

 Vδ2+Vγ9+

32.7 (12.9–52.2)

21.1 (4.70–32.1)

54.3 (31.1–65.7)

< 0.001

0.043

< 0.001

0.016

 Vδ2+Vγ9

0.16 (0.07–0.46)

0.16 (0.00–0.44)

0.08 (0.03–0.29)

NS

Vδ1Vδ2

22.8 (15.5–39.5)

35.6 (27.1–58.2)

22.8 (17.1–30.3)

0.001

NS

< 0.001

0.002

 Vδ1Vδ2Vγ9+

1.23 (0.36–2.91)

1.10 (0.33–2.53)

2.42 (1.25–3.83)

0.010

NS

0.009

NS

 Vδ1Vδ2Vγ9

22.0 (14.7–36.1)

33.1 (24.5–55.3)

18.1 (10.7–26.4)

< 0.001

NS (0.073)

< 0.001

< 0.001

  1. Values are the median (IQR). Percentages of each population in total γδ T cells are shown
  2. p values (K-W test) were obtained by Kruskal-Wallis analyses, and if they were statistically significant, then padj values were calculated using multivariate linear regression analyses adjusted for age and sex
  3. HCs healthy controls, IFN-β interferon-β, IQR interquartile ranges, K-W Kruskal-Wallis, MS multiple sclerosis, NS not significant, w/ with