| |
Untreated MS (n = 35)
|
MS w/ IFN-β (n = 21)
|
HCs (n = 44)
|
p value (K-W test)
|
padj value
|
|---|
|
Untreated MS vs. HCs
|
MS w/ IFN-β vs. HCs
|
Untreated MS vs. MS w/ IFN-β
|
|---|
|
Naïve (CD27−IgD+)
|
46.3 (27.9–56.8)
|
48.9 (37.7–58.9)
|
51.8 (41.4–60.6)
|
NS
|
–
|
–
|
–
|
|
Memory (CD27+)
|
14.8 (10.3–27.0)
|
9.84 (6.89–15.2)
|
22.7 (16.9–29.9)
|
< 0.001
|
NS
|
< 0.001
|
0.009
|
|
CS+ memory (CD27+IgD−)
|
12.4 (9.27–24.8)
|
7.97 (6.10–14.0)
|
18.8 (14.4–25.2)
|
< 0.001
|
NS
|
< 0.001
|
0.006
|
|
CS− memory (CD27+IgD+)
|
1.91 (0.83–2.68)
|
0.99 (0.85–1.67)
|
3.49 (2.49–4.67)
|
< 0.001
|
NS (0.058)
|
< 0.001
|
NS
|
|
Plasmablasts (CD38highCD20−)
|
0.31 (0.14–0.65)
|
0.32 (0.25–0.53)
|
0.37 (0.24–0.67)
|
NS
|
–
|
–
|
–
|
|
Transitional (CD24highCD38high)
|
3.16 (1.75–5.93)
|
5.90 (1.92–7.66)
|
3.14 (2.32–4.45)
|
NS
|
–
|
–
|
–
|
- Values are the median (IQR). Percentages of each population in total B cells are shown
- p values (K-W test) were obtained by Kruskal-Wallis analyses, and if they were statistically significant, then padj values were calculated using multivariate linear regression analyses adjusted for age and sex
- CS+ class-switched, CS− non-class-switched, HCs healthy controls, IFN-β interferon-β, IQR interquartile ranges, K-W Kruskal-Wallis, MS multiple sclerosis, NS not significant, w/ with
