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Table 1 The mechanism of action of drugs

From: Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants

Drug

Mechanisms

Anti-HMGB1-neutralizing antibody (HMGB1-Ab)

Inactivation of HMGB1

LPS-RS

Blockade of TLR4

Low molecular weight heparin (LMWH)

Blockade of RAGE

AMD3100

Blockade of CXCR4

TAK-242

Blockade of TLR4

FPS-ZM1

Blockade of RAGE

Thrombomodulin α

Inactivation of HMGB1

Liposomal clodronate (Cld)

Depletion of macrophage

Minocycline (Mino)

Inactivation of macrophage/microglia

Ethyl pyruvate (EP)

Inhibition of HMGB1 release from macrophage

Argatroban (AT)

Inhibition of thrombin

Warfarin (War)

Antagonism of vitamin K

Dabigatran (Dabi)

Inhibition of thrombin

Rivaroxaban

Inhibition of Factor Xa

Aspirin (ASA)

Inhibition of COX

Clopidogrel (Clo)

Blockade of P2Y12

  1. The mechanism of action of major agents used in the present study