Drug | Mechanisms |
---|---|
Anti-HMGB1-neutralizing antibody (HMGB1-Ab) | Inactivation of HMGB1 |
LPS-RS | Blockade of TLR4 |
Low molecular weight heparin (LMWH) | Blockade of RAGE |
AMD3100 | Blockade of CXCR4 |
TAK-242 | Blockade of TLR4 |
FPS-ZM1 | Blockade of RAGE |
Thrombomodulin α | Inactivation of HMGB1 |
Liposomal clodronate (Cld) | Depletion of macrophage |
Minocycline (Mino) | Inactivation of macrophage/microglia |
Ethyl pyruvate (EP) | Inhibition of HMGB1 release from macrophage |
Argatroban (AT) | Inhibition of thrombin |
Warfarin (War) | Antagonism of vitamin K |
Dabigatran (Dabi) | Inhibition of thrombin |
Rivaroxaban | Inhibition of Factor Xa |
Aspirin (ASA) | Inhibition of COX |
Clopidogrel (Clo) | Blockade of P2Y12 |