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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

Fig. 1

URMC-099 treatment reverses microgliosis and BBB leak following orthopedic surgery. Nine-month-old male mice underwent open tibial fracture and were terminated 24 h after surgery. URMC-099 was given i.p. at 10 mg/kg, three doses before surgery and two doses after surgery based on Marker et al. [14]. a Representative images of F4/80 microglial/macrophage staining (top panels) and IgG staining (bottom panels) show that URMC-099 significantly attenuated microgliosis in the hippocampus. b Differences in microglia cell numbers were quantified by unbiased stereology. c IgG relative optical density was quantified to measure differences in BBB opening. N = 2–4; results presented as mean ± SEM; *P < 0.05, ***P < 0.001, versus surgery + vehicle group; one-way ANOVA with Dunnett’s multiple comparison test

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Journal of Neuroinflammation

ISSN: 1742-2094