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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

Fig. 3

URMC-099 prophylaxis does not inhibit the peripheral innate immune response. Three-month-old mice received three doses i.p. of URMC-099 (10 mg/kg) prior to undergoing sham or orthopedic surgery. Whole blood was isolated 6 h post-surgery and used for cytokine/chemokine profiling and flow cytometry. ac URMC-099 prophylaxis had no effect on surgery-induced plasma G-CSF, CXCL1, and CXCL2 levels at 6 h post-surgery. de URMC-099 prophylaxis had no effect on the surgery-induced increase in neutrophils at 6 h post-surgery. fh URMC-099 prophylaxis and surgery did not significantly alter inflammatory (g) and patrolling monocyte (h) populations at 6 h post-surgery. N = 4; results presented as mean ± SEM; *P < 0.05, versus surgery + vehicle group; one-way ANOVA with Dunnett’s multiple comparison test

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