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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

Fig. 5

URMC-099 prophylaxis abrogates orthopedic surgery-induced deficits in the Memory Load task. Three-month-old mice received three doses i.p. of URMC-099 (10 mg/kg) prior to undergoing sham or orthopedic surgery. a An illustration of the Memory Load Object Discrimination test. b Illustration depicting the objects used for the task. c URMC-099 prevented the surgery-induced impairments in the Memory Load test overall. N = 10; results presented as mean ± SEM; *P < 0.05, **P < 0.01, versus surgery + vehicle group; repeated-measures ANOVA with Dunnett’s multiple comparison test

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