Fig. 1

a–c Fundus image of mouse retina with segmentation of OCT, where each green line depicts a B-scan. a Volume scan taken from raster scan of the optic nerve head. Area in blue includes the region of calculated volume. b Peripapillary ring and c horizontal and vertical line scans. d–f Examples of B-scans obtained from volume (d), peripapillary ring (e), and (f) line scans. On the right half of each B-scan, the results of the semi-automated segmentation of the layers are shown with retinal layers labeled. g Horizontal B-scan in a SJL/J mouse, with atrophy of outer retinal layers, a characteristic finding in retinal degeneration 1. h Schematic representation of a retina dissected from an eyeball (left) and a whole mount for histological analysis (right). The dotted line represents cuts made on the retina; the red squares represent areas analyzed in the central (1), mid-peripheral (2), and far-peripheral retina (3)