Fig. 2

a Clinical EAE score of C57Bl/6J mice immunized with MOG or MBP peptide, as well as TCR^2D2 transgenic mice immunized with MOG peptide. b Change of the inner retinal layers of TCR^WT and TCR^2D2 mice. c IRL change of C57BL/6J mice immunized with MBP. d Retinal wholemounts stained by βIII-tubulin antibody from groups indicated in a. The representative images display the most severe disease progression. e The bar graph shows the RGC density 120 days after immunization. Time courses and bar graphs represent the pooled mean ± SEM of two separate EAE experiments each with at least four animals per group, *P > 0.05; **P < 0.01; ***P < 0.001; time courses (area under the curve) were compared to sham, and bar graph compared to sham TCR^WT mice by ANOVA with Dunnett’s post hoc test