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Table 3 Summary of EAE experiments and results

From: Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis

Figures Strain Encephalytogenic peptide OCT follow-up period OCT time points (months after immunization) OCT findings Histological findings Additional findings
2, 3, 4, 6 WT C57Bl/6J MOG35–55 120 days 0, 0.5, 1, 2, 3, 4 Initial IRL swelling mirroring EAE onset and peak, followed by progressive thinning Optic neuritis (T cell infiltration, microglial activation, and demyelination) with 32% RGC loss. Decrease of myelinated nerve fibers and destruction of the myelin structure. Decreased visual acuity (OKR)
2, 3 WT C57Bl/6J MBP 120 days 0, 0.5, 1, 2, 3, 4 No change No optic neuritis or RGC loss  
2, 3 TCR2D2 MOG35–55 120 days 0, 0.5, 1, 2, 3, 4 IRL atrophy already present at 2 weeks Severe optic neuritis with 49% RGC loss  
5 WT C57Bl/6J MOG35–55 9 months 0, 1, 2, 5, 7, 9 Progressive IRL and INL thinning, more pronounced during the first 2 months 54% RGC loss  
6 SJL/J PLP139–151 7 months 0, 1, 2, 5, 7 Progressive IRL atrophy, also present to a lesser degree in sham-immunized mice