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Table 3 Summary of EAE experiments and results

From: Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis

Figures

Strain

Encephalytogenic peptide

OCT follow-up period

OCT time points (months after immunization)

OCT findings

Histological findings

Additional findings

2, 3, 4, 6

WT C57Bl/6J

MOG35–55

120 days

0, 0.5, 1, 2, 3, 4

Initial IRL swelling mirroring EAE onset and peak, followed by progressive thinning

Optic neuritis (T cell infiltration, microglial activation, and demyelination) with 32% RGC loss. Decrease of myelinated nerve fibers and destruction of the myelin structure.

Decreased visual acuity (OKR)

2, 3

WT C57Bl/6J

MBP

120 days

0, 0.5, 1, 2, 3, 4

No change

No optic neuritis or RGC loss

 

2, 3

TCR2D2

MOG35–55

120 days

0, 0.5, 1, 2, 3, 4

IRL atrophy already present at 2 weeks

Severe optic neuritis with 49% RGC loss

 

5

WT C57Bl/6J

MOG35–55

9 months

0, 1, 2, 5, 7, 9

Progressive IRL and INL thinning, more pronounced during the first 2 months

54% RGC loss

 

6

SJL/J

PLP139–151

7 months

0, 1, 2, 5, 7

Progressive IRL atrophy, also present to a lesser degree in sham-immunized mice

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