Fig. 7
From: Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain
Prostatitis induced CXCL1 expression in spinal cord dorsal horn and contributed to mechanical allodynia. a ELISA analysis showing CXCL1 expression was increased in spinal cord dorsal horn 5 weeks after carrageenan injection. *P < 0.05, vs. control (con, saline-treated group), Student’s t test. n = 4 mice per group. b ELISA analysis shows decreased CXCL1 release in the CSF in the carrageenan-injected group at 3 h after the intrathecal injection of CBX (5 μg). *P < 0.05, vs. control (con, saline-treated group); #P < 0.05, vs. the vehicle group. One-way ANOVA, followed by post hoc Bonferroni test. n = 4 mice/group. c Prostatitis-induced mechanical allodynia in the lower abdominal area were partially reversed by intrathecal injection of the CXCL1 neutralizing antibody (5 μg) at 5 weeks after carrageenan injection. d Prostatitis-induced mechanical allodynia in the lower abdominal area was partially reversed by intrathecal injection of the CXCR2 antagonist SB225002 (20 μg) at 5 weeks after carrageenan injection. BL, baseline. *P < 0.05, vs. Carr 5w, two-way ANOVA, followed by post-hoc Bonferroni test. n = 6 mice/group. All data are expressed as mean ± S.E.M. Arrows indicate drug injection