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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Dynamic response of microglia/macrophage polarization following demyelination in mice

Fig. 2

Temporal profile of the demyelinating lesions formed within the dorsal spinal cord after stereotaxic injections. a Representative light micrographs of LFB staining of the dorsal columns following PBS (CTR group), LPC, and LPS injections at different times. Scale bar = 200 μm. b Illustration of quantification method for LFB staining. OD ratio was calculated to measure the severity of demyelination with internal control. c Temporal changes in the OD ratio of LFB-stained dorsal lesions. For each time-point, the OD ratio was compared to the CTR group (**p < 0.01, ***p < 0.001, ****p < 0.0001) and the LPC group (××p < 0.01, ××××p < 0.0001); for each group, OD ratio was compared to 3 dpi (####p < 0.0001), 5 dpi (+p < 0.05, ++p < 0.01, ++++p < 0.0001), 7 dpi (&p < 0.05, &&&&p < 0.0001), 10 dpi ($p < 0.05, $$$$p < 0.0001), and 14 dpi (!!!!p < 0.0001). Data were collected from three animals per group at each time-point (n = 3 mice)

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