Fig. 4

Temporal changes in the neurobehavioral performance of dorsal demyelination mouse models. a Body weight (normalized to each baseline at − 1 dpi) changes at different time-points after focal injection of PBS, LPC, and LPS into the dorsal column of the spinal cord. For each time-point, no statistical significance in body weight between the LPC/LPS groups and CTR group was noted; for each group, body weight was compared to − 1 dpi (#p < 0.05, ####p < 0.0001), 3 dpi (++p < 0.01, +++p < 0.001, ++++p < 0.0001), 7 dpi ($p < 0.05), and 14 dpi (no statistical significance for all groups). b Rotarod performance (normalized to each baseline at − 1 dpi) at different time-points. No statistical significance between the LPC or LPS group and CTR group were observed at any given time-point; for each group, no statistical significance between different time-points except when compared to − 1 dpi (#p < 0.05) and 3 dpi (+p < 0.05) in LPC group. c Grip strength (normalized to each baseline at − 1 dpi) at different time-points. For each time-point, no statistical significance in forelimb/grip strength was noted between the LPC/LPS groups and CTR group; for each group, no statistical significance between different time-points except when compared to − 1 dpi (#p < 0.05, ##p < 0.01, ###p < 0.001). d Balance beam score (normalized to each baseline at − 1 dpi) at different time-points. For each time-point, the balance beam score was compared to the CTR group (***p < 0.001, ****p < 0.0001) and the LPC group (×p < 0.05); for each group, balance beam score was compared to − 1 dpi (#p < 0.05, ####p < 0.0001), 3 dpi (++p < 0.01, ++++p < 0.0001), 5 dpi (&p < 0.05, &&p < 0.01, &&&&p < 0.0001), 7 dpi ($$p < 0.01, $$$$p < 0.0001), 10 dpi (!p < 0.05,!!!!p < 0.0001), and 14 dpi (no statistical significance for all groups). Data were collected from nine animals per group (n = 9 mice) with experimenter blinding