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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Dynamic response of microglia/macrophage polarization following demyelination in mice

Fig. 5

Dynamic response of oligodendrocyte-linage cells in localization and cell density following dorsal demyelination. a Representative photomicrographs of OPCs (Olig2+Pdgfrα+) in the dorsal demyelination area in CTR, LPC, and LPS groups at 3, 10, and 21 dpi. Dashed white line indicates the margins of the dorsal columns. Representative double labelling is indicated by arrowhead and single labelling is indicated by arrow in the inset for better view. Scale bar, 50 μm for panel figure; 20 μm for inset. b Quantification of OPC density within the dorsal column (Olig2+Pdgfrα+ cells/mm2) at the lesion site in the three groups at 3, 10, and 21 dpi. Cell density was compared to the CTR group (*p < 0.05, ****p < 0.0001) and the LPC group (×××p < 0.001, ××××p < 0.0001) at each given time-point; for each group, cell density was compared to 3 dpi (#p < 0.05, ####p < 0.0001) and 10 dpi (++++p < 0.0001). c Representative photomicrographs of mature OLs in the dorsal demyelination area (GST-π+CC1+) in CTR, LPC, and LPS groups at 3, 10, and 21 dpi (scale bar = 50 μm). Representative double labelling is indicated by arrowhead in the inset for better view (scale bar = 20 μm). d Quantification of mature OL density (GST-π+CC1+ cells/mm2) within the dorsal column at the lesion site in the three groups at 3, 10, and 21 dpi. The cell density was compared to the CTR group (**p < 0.01, ****p < 0.0001) and the LPC group (×××p < 0.001, ××××p < 0.0001) at each given time-point; for each group, cell density was compared to 3 dpi (####p < 0.0001) and 10 dpi (++++p < 0.0001). Data were collected from three animals per group at each time-point (n = 3 mice)

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