Fig. 9

Correlations between demyelination severity, sensorimotor function, and M/M polarization. a Positive correlation between demyelination severity (OD ratio) and sensorimotor function (balance beam) was statistically significant in the LPC group (left; r = 0.8791, p = 0.0211), but not in the LPS group (right; r = 0.7282, p = 0.1008). b Negative correlations between demyelination (OD ratio) severity and M/M polarization in the LPC group (Left: CD16/32⁺Iba1⁺, r = − 0.9712, p < 0.0001; CD206⁺Iba1⁺, r = − 0.4797, p = 0.1913. Right: CD86⁺Iba1⁺, r = − 0.6969, p = 0.0369; Arg1Iba1⁺, r = − 0.8041, p = 0.0090). c Negative correlations between demyelination (OD ratio) severity and M/M polarization in the LPS group (Left: CD16/32⁺Iba1⁺, r = − 0.3886, p = 0.3013; CD206⁺Iba1⁺, r = − 0.8549, p = 0.0033. Right: CD86⁺Iba1⁺, r = − 0.8192, p = 0.0069; Arg1Iba1⁺, r = − 0.5233, p = 0.1483)