Fig. 2
From: MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
There is increased astrogliosis in the motor cortex of prpTDP-43A315T-UeGFP. a Breeding strategy to generate prpTDP-43A315T-UeGFP mice upon crossbreeding of prpTDP-43A315T and UCHL1-eGFP mice. b A representative low-magnification image of motor cortex of WT-UeGFP mice showing presence of few astrocytes with high-magnification images from layer 5 of motor cortex in (d and e). c A representative low image of motor cortex of prpTDP-43A315T-UeGFP mice showing presence of increased number of astrocytes with magnification images from layer 5 of motor cortex of prpTDP-43A315T-UeGFP mice showing astrocytes in close proximity to corticospinal motor neurons (f and g). h Quantification of number of astrocytes in layer 2/3 and i layer 5 shows a progressive increase in astrocytes in the motor cortex. Scale bar: a, d = 10 μm; b, c, e, f = 20 μm. *p < 0.05, **p < 0.001, ***p < 0.0001