Fig. 3
From: MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
Microgliosis is prominent in the motor cortex of prpTDP-43A315T-UeGFP. a A representative image of motor cortex of WT-UeGFP mice showing normal presence of microglia (Iba1+) with high-magnification images from layer 2/3 and layer 5 of motor cortex in (c and d) respectively. b A representative image of motor cortex of prpTDP-43A315T-UeGFP mice showing microgliosis with high-magnification images from layer 2/3, and layer 5 of motor cortex showing activated microglia adjacent to the apical dendrite and soma of corticospinal motor neurons in (e and f), respectively. g, h Quantification of number of microglia in layer 2/3 (g) and layer 5 (h) shows no difference in number of total microglia the motor cortex. i, j Quantification of activated microglia in layer 2/3 (i) and layer 5 shows a progressive increase of activated microglia in the motor cortex of prpTDP-43A315T-UeGFP mice. Scale bar: a, d = 10 μm; b, c, e, f = 20 μm. *p < 0.01, ***p < 0.0004, ****p < 0.0001