Fig. 4
From: MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
Microgliosis with respect to TDP-43 pathology is conserved among species. a A representative image of motor cortex of WT-UeGFP mice with healthy CSMN and normal levels of microglia and astrocytes. b A representative image of motor cortex of prpTDP-43A315T-UeGFP with activated microglia surrounding degenerating CSMN apical dendrites. Insets enlarged to the right (b’). c A representative image of rod-like microglia near a degenerating CSMN apical dendrite in the motor cortex of prpTDP-43A315T-UeGFP. d A representative image of layer 5 of the primary motor cortex (Brodmann area 4) isolated from normal controls showing healthy Betz cells and normal levels of microglia and astrocytes. e, f A representative image of layer 5 of the primary motor cortex (Brodmann area 4) isolated from postmortem ALS cases with TDP-43 pathology demonstrate presence of smaller Betz cells (Map 2+) surrounded by activated microglia (Iba1+) (e), and rod-like microglia near a degenerating apical dendrites of Betz cells are observed with prominent astrogliosis (f). Scale bar = 20 μm