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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

Fig. 8

Neuronal expression of MCP1 increases in ALS cases with TDP-43 and ALS-FTLD cases with TDP-43 pathology. Images of layer 5 of the primary motor cortex (Brodmann area 4) isolated from normal controls and postmortem ALS cases. a, b Normal controls express low levels of MCP1 and Betz cells (Map 2+) have healthy apical dendrites (arrows). c, d ALS cases with TDP-43 pathology have smaller Betz cells or degenerating Betz cells (asterisks) that express MCP1 and they are surrounded by activated microglia (Iba1+, arrowhead). e, f ALS-FTLD with TDP-43 pathology cases have Betz cells expressing high levels of MCP1 (asterisk), and there are numerous degenerating apical dendrites (arrows) with activated microglia (arrowheads) near degenerating apical dendrites. Scale bar = 20 μm

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