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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

Fig. 4

The effect of Mc1r siRNA on neurological functions, brain water content and BBB integrity at 24 h after ICH. a The expression of Mc1r was obviously reduced in the right hemisphere by Mc1r siRNA at 24 h post-ICH. &P < 0.05 vs Scr siRNA. b–e Knockdown of Mc1r using Mc1r siRNA aggravated neurological deficits and increased brain edema and BBB permeability at 24 h following ICH. n = 6 per group. #P < 0.05 vs sham; *P < 0.05 vs ICH + vehicle; @P < 0.05 vs ICH + NDP-MSH, and ICH + NDP-MSH + Scr siRNA. Scr siRNA, scrambled siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094